GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7267979 | 1 | rs6107047 | chr20:25442097 | NINL | chr20:25433338-25566153:- | -0.37 | -7.51 | 2.94E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6107047 | chr20:25442097 | PYGB | chr20:25228706-25278647:+ | -0.13 | -3.36 | 0.00084 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs73086581 | 1 | rs6107386 | chr20:3972756 | MAVS | chr20:3827449-3856761:+ | -0.24 | -3.61 | 0.000336 | Response to antidepressants in depression |
| THCA | cis | rs73086581 | 1 | rs6107391 | chr20:3983083 | MAVS | chr20:3827449-3856761:+ | -0.23 | -3.55 | 0.000419 | Response to antidepressants in depression |
| THCA | cis | rs73086581 | 1 | rs6107393 | chr20:3987738 | MAVS | chr20:3827449-3856761:+ | -0.24 | -3.73 | 0.000212 | Response to antidepressants in depression |
| THCA | cis | rs1552244 | 1 | rs61077902 | chr3:10126153 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.27 | 2.4E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs61077902 | chr3:10126153 | VHL | chr3:10183319-10193744:+ | -0.18 | -4.13 | 4.3E-5 | Alzheimer's disease |
| THCA | cis | rs3740713 | 1 | rs61081934 | chr11:18454317 | LDHC | chr11:18433853-18472792:+ | -0.3 | -3.57 | 0.000386 | Amyotrophic lateral sclerosis (sporadic) |
| THCA | cis | rs2129782 | 1 | rs61087653 | chr8:89418326 | MMP16 | chr8:89049462-89339717:- | 0.32 | 4.99 | 8.29E-7 | Electrodermal activity |
| THCA | cis | rs2129782 | 1 | rs61088422 | chr8:89438875 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs2275426 | 1 | rs61102033 | chr1:46382441 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.03 | 1.29E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61102033 | chr1:46382441 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.1 | 4.85E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61102033 | chr1:46382441 | MMACHC | chr1:45965856-45976737:+ | -0.21 | -4.48 | 9.43E-6 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs61102033 | chr1:46382441 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.43 | 4.2E-16 | Body mass index |
| THCA | cis | rs2129782 | 1 | rs61109805 | chr8:89435101 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |